The incomplete germline VLR genes are flanked by hundreds of LRR

Download scientific diagram | The incomplete germline VLR genes are flanked by hundreds of LRR cassettes. The noncoding intervening sequence of germline VLR is replaced by LRR fragments that are sequentially copied from the flanking LRR cassettes. Mature complete VLR genes are assembled from either the LRRNT or LRRCT end in a stepwise fashion that is directed by short sequence homology between the donor and recipient LRR sequences. This figure was modified from [6]. from publication: Immune Related Genes Underpin the Evolution of Adaptive Immunity in Jawless Vertebrates | The study of immune related genes in lampreys and hagfish provides a unique perspective on the evolutionary genetic underpinnings of adaptive immunity and the evolution of vertebrate genomes. Separated from their jawed cousins at the stem of the vertebrate lineage, these | Vertebrates, Adaptive Immunity and Lymphocytes | ResearchGate, the professional network for scientists.

Evolution of variable lymphocyte receptor B antibody loci in jawless vertebrates

Masayuki HIRANO, Emory University, GA, EU

Evolution of variable lymphocyte receptor B antibody loci in jawless vertebrates

Support for three possible topologies for the hagfish/lamprey/bony

Max COOPER, Emory University, GA, EU

Sequence variability of inshore hagfish VLRs. Variability is indicated

Variable lymphocyte receptors in hagfish

JCI Insight - Identification of human plasma cells with a lamprey monoclonal antibody

Regulation of antigen‐receptor gene assembly in hagfish

Support for three possible topologies for the hagfish/lamprey/bony

Diversity and Function of Adaptive Immune Receptors in a Jawless Vertebrate

Nathanael MCCURLEY, Research Scientist, PhD

Assembly of the LRR-encoding gene segments.(a) Organization and

Antibodies from Lampreys as Smart Anti-Glycan Reagents (SAGRs): Perspectives on Their Specificity, Structure, and Glyco-genomics

Sabyasachi DAS, Instructor, PhD, Emory University, GA