Download scientific diagram | The incomplete germline VLR genes are flanked by hundreds of LRR cassettes. The noncoding intervening sequence of germline VLR is replaced by LRR fragments that are sequentially copied from the flanking LRR cassettes. Mature complete VLR genes are assembled from either the LRRNT or LRRCT end in a stepwise fashion that is directed by short sequence homology between the donor and recipient LRR sequences. This figure was modified from [6]. from publication: Immune Related Genes Underpin the Evolution of Adaptive Immunity in Jawless Vertebrates | The study of immune related genes in lampreys and hagfish provides a unique perspective on the evolutionary genetic underpinnings of adaptive immunity and the evolution of vertebrate genomes. Separated from their jawed cousins at the stem of the vertebrate lineage, these | Vertebrates, Adaptive Immunity and Lymphocytes | ResearchGate, the professional network for scientists.
Evolution of variable lymphocyte receptor B antibody loci in jawless vertebrates
Masayuki HIRANO, Emory University, GA, EU
Evolution of variable lymphocyte receptor B antibody loci in jawless vertebrates
Support for three possible topologies for the hagfish/lamprey/bony
Max COOPER, Emory University, GA, EU
Sequence variability of inshore hagfish VLRs. Variability is indicated
Variable lymphocyte receptors in hagfish
JCI Insight - Identification of human plasma cells with a lamprey monoclonal antibody
Regulation of antigen‐receptor gene assembly in hagfish
Support for three possible topologies for the hagfish/lamprey/bony
Diversity and Function of Adaptive Immune Receptors in a Jawless Vertebrate
Nathanael MCCURLEY, Research Scientist, PhD
Assembly of the LRR-encoding gene segments.(a) Organization and
Antibodies from Lampreys as Smart Anti-Glycan Reagents (SAGRs): Perspectives on Their Specificity, Structure, and Glyco-genomics
Sabyasachi DAS, Instructor, PhD, Emory University, GA