The absolute penis weight and length at ages 28 ( A ) and 130–150 ( B )

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Download scientific diagram | The absolute penis weight and length at ages 28 ( A ) and 130–150 ( B ) days in rats treated with DES, with or without coadministration of ICI, DHT, or T, from Postnatal Days 1 to 6, except in the case of DHT, which was also coadministered from Postnatal Days 7 to 12 or 13 to 18 in rats examined at age 130–150 days. Note that the coadministration of ICI, DHT, or T generally restored the DES-induced losses in both penile measurements to almost the control level in both age groups (except for DHT and T in the 28-day-old group), in contrast to their further exacerbation by DHT coadministration from Postnatal Days 13 to 18 (Table 3). Data are expressed as the mean 6 SEM. *Significantly ( P , 0.05) different from controls. from publication: Estrogen-Induced Developmental Disorders of the Rat Penis Involve Both Estrogen Receptor (ESR)- and Androgen Receptor (AR)-Mediated Pathways | This study tested the hypothesis that the estrogen receptor (ESR) pathway, androgen receptor (AR) pathway, or both mediate estrogen-induced developmental penile disorders. Rat pups received diethylstilbestrol (DES), with or without the ESR antagonist ICI 182,780 (ICI) or the | Androgen Receptors, Penis and Estrogen Receptor | ResearchGate, the professional network for scientists.

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